246 REGULATION OF CHONDROGENIC DIFFERENTIATION BY NFκβ IN MESENCHYMAL PROGENITOR CELLS
نویسندگان
چکیده
منابع مشابه
epigenetic regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in culture
management of mesenchymal stem cells (mscs) capabilities to differentiate into osteogenic and chondrogenic lineages would be of utmost importance for their future use in difficult to treat cases of destroyed bone and cartilage. thus, an understanding of the epigenetic mechanisms as important modulators of stem cell differentiation might be useful. epigenetic mechanism refers to a process that r...
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In vitro expansion of mesenchymal stem cell (MSCs) into large number is necessary for their application in cell-based treatment of articular cartilage defects. On the other hand, some studies have indicated that BIO (6-Bromoindirubin-3-Oxime) possesses mitogenic effects on cell culture. The objective of the present study was to examine the effect of BIO on in vitro expansion and chondrogenic di...
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Mechanical interaction of cells and their surroundings are prominent in mechanically active tissues such as cartilage. Chondrocytes regulate their growth, matrix synthesis, metabolism, and differentiation in response to mechanical loadings. Cells sense and respond to applied physical forces through mechanosensors such as integrin receptors. Herein, we examine the role of mechanical stimulation ...
متن کاملEpigenetic Regulation of Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells in Culture
Management of mesenchymal stem cells (MSCs) capabilities to differentiate into osteogenic and chondrogenic lineages would be of utmost importance for their future use in difficult to treat cases of destroyed bone and cartilage. Thus, an understanding of the epigenetic mechanisms as important modulators of stem cell differentiation might be useful. Epigenetic mechanism refers to a process that r...
متن کاملGas6, a new regulator of chondrogenic differentiation from mesenchymal cells.
The mesenchymal cell line C3H10T1/2 can be preferentially induced toward chondrogenesis by culturing as a micromass in the presence of bone morphogenetic protein 2. To screen new regulator genes for chondrogenic differentiation, we performed differential display polymerase chain reaction and identified growth arrest-specific 6 (Gas6) as a gene that was clearly downregulated by this induction of...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2009
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(09)60268-5